产品货号：
Z15845
中文名称：
DIRAS3抗体
英文名称：
Anti-DIRAS3 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-DIRAS3 Antibody |
| 指标别名 | DIRAS family GTP-binding RAS-like 3;ARHI;NOEY2 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,WB |
| 基因名称 | DIRAS3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | DIRAS3 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human DIRAS3.The immunogen is located within the last 50 amino acids of DIRAS3. |
| 计算分子量 | 26kDa |
| 成分 | DIRAS3 antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | DIRAS3 antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | DIRAS3 is a member of the ras superfamily,and is expressed in normal ovarian and breast epithelial cells,but not in ovarian and breast cancers.It is an imprinted gene,with mono-allelic expression of the paternal allele,which is associated with growth suppression and down-regulation of cyclin D1 promoter activity and induction of p21 (WAF/CIP1).Thus,this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers (1).DIRAS3 has been shown to induce autophagy in human ovarian cancer cells by blocking PI3K signaling,inhibiting the mammalian target of rapamycin (TOR),upregulating ATG4,and colocalizing with LC3 in autophagosomes (2).DIRAS also interacts with C-RAF and downregulates mitogen-activated protein kinase kinases (MEK) to restrict cell migration (3). |
| Uniprot ID | O95661 |
| 基因名全称 | DIRAS family,GTP-binding RAS-like 3 |
| 蛋白名全称 | DIRAS family,GTP-binding RAS-like 3 |
| 推荐稀释比 | DIRAS3 antibody can be used for detection of DIRAS3 by Western blot at 1 ～ 2μg/mL.Antibody validated:Western Blot in human samples.All other applications and species not yet tested. |
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